The paper outlines curriculum development activities that have been done in science education in the Slovak Republic as a result of an international collaboration within the frame of the Leonardo da Vinci II pilot project Computerised Laboratory in Science and Technology Teaching - ``ComLab-SciTech''. The created teaching and learning materials include integration of science curricula in two meanings: an integration of knowledge and methodology of physics, chemistry and biology, as well as an integration of various true and virtual computerised methods of experiments. The materials contain suggestions for student investigative activities, in which life science processes are studied with the use of laboratory models.