Over the last decade there is an intensive discussion within the Information Systems (IS) and Informatics community about the characteristics and identity of the discipline. Simultaneously with the discussion, there is an ongoing debate on essential skills and capabilities of IS and Business Informatics graduates as well as the profile of IS programs. With this paper we recognize the need for different IS perspectives resulting in diverse study profiles. We developed a framework for structuring information systems study programs and characterized some of the differences in study programs. The results from this study are based on a survey and workshops with domain exerts, both from academia and practice. The descriptive results from the survey are presented, and show the diversity of study programs, both on master and bachelor level. As an example for an IS profile we summarize a reference structure for Business Informatics study programs, which aims to provide guidance for curriculum development and to stimulate further debate on IS curriculum development.